Family Foundation Model

← All families

Family A G protein-coupled receptor

The rhodopsin-like receptors, the largest and most drugged receptor class, and the family the sibling GPCR Foundation Model covers on its own.

Targets

173

servable in this model

Ligands

5,870

measured here and in at least one other family

Comparisons

25,162

involving this family

The data

QuantityValue
Measurements25,162
Activity range, pActivity2.13 to 12.52
Median activity6.39

Endpoints

EndpointMeasurements
IC5012,423
Ki12,047
EC50641
Kd51

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two5,062
Three494
Four or more314

Which families those compounds also reach

FamilyShared compounds
Voltage-gated ion channel2,166
Electrochemical transporter1,980
Cytochrome P4501,280
Ligand-gated ion channel298
Nuclear receptor237
Oxidoreductase213

Targets in this family

Accession
A8K2H7
O00421
O14842
O43193
O43194
O43603
O43613
O43614
O95136
P07550
P08172
P08173
P08588
P08908
P08912
P08913
P0DMS8
P11229
P13945
P14416
P16473
P18089
P18825
P20309
P21452
P21453
P21462
P21554
P21728
P21730
P21731
P21917
P21918
P22888
P24530
P25021
P25024
P25025
P25090
P25100
P25101
P25103
P25105
P25106
P25116
P25929
P28221
P28222
P28223
P28335
P28336
P28566
P29274
P29275
P29371
P30411
P30518
P30542
P30550
P30556
P30559
P30872
P30874
P30939
P30968
P30989
P31391
P32238
P32239
P32245
P32246
P32247
P32249
P32745
P33032
P34969
P34972
P34995
P35346
P35348
P35367
P35368
P35372
P35408
P35414
P35462
P37288
P41143
P41145
P41146
P41231
P41595
P41597
P41968
P43088
P43115
P43116
P43119
P46089
P46092
P46093
P46095
P46663
P47898
P47900
P47901
P48039
P49146
P49238
P49286
P49682
P50052
P50391
P50406
P51582
P51677
P51679
P51681
P51684
P51685
P55085
P61073
Q01726
Q13258
Q13304
Q13639
Q14330
Q15077
Q15391
Q15722
Q15761
Q16581
Q5NUL3
Q6W5P4
Q7Z601
Q8IYL9
Q8TDS4
Q8TDS5
Q8TDU6
Q8TDV5
Q92633
Q92847
Q969F8
Q969V1
Q96G91
Q96LA9
Q96LB1
Q96P65
Q96RI0
Q96RJ0
Q99527
Q99677
Q99705
Q9BPV8
Q9BXA5
Q9H1C0
Q9H228
Q9H244
Q9H255
Q9H3N8
Q9HBW0
Q9HBX9
Q9HC97
Q9NPC1
Q9NQS5
Q9NS75
Q9P296
Q9UBY5
Q9UKP6
Q9UNW8
Q9Y271
Q9Y2T6
Q9Y5N1
Q9Y5Y4