Heme enzymes that metabolize most small-molecule drugs. Usually a counter-target rather than a target.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 17,917 |
| Activity range, pActivity | -0.12 to 10.82 |
| Median activity | 5.24 |
| Endpoint | Measurements |
|---|---|
| IC50 | 17,061 |
| Ki | 782 |
| EC50 | 65 |
| Kd | 9 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 4,190 |
| Three | 685 |
| Four or more | 308 |
| Family | Shared compounds |
|---|---|
| Family A G protein-coupled receptor | 1,280 |
| Voltage-gated ion channel | 1,267 |
| Kinase | 1,069 |
| Protease | 560 |
| Oxidoreductase | 548 |
| Electrochemical transporter | 473 |