Channels that open in response to membrane potential. hERG sits here, which is why this family turns up in safety work.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 14,089 |
| Activity range, pActivity | 1.0 to 11.0 |
| Median activity | 5.25 |
| Endpoint | Measurements |
|---|---|
| IC50 | 12,420 |
| Ki | 1,503 |
| EC50 | 121 |
| Kd | 45 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 4,770 |
| Three | 784 |
| Four or more | 220 |
| Family | Shared compounds |
|---|---|
| Family A G protein-coupled receptor | 2,166 |
| Cytochrome P450 | 1,267 |
| Kinase | 1,184 |
| Electrochemical transporter | 477 |
| Protease | 469 |
| Nuclear receptor | 300 |