Membrane transporters that move solutes against a gradient, including the monoamine transporters.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 16,593 |
| Activity range, pActivity | 0.82 to 10.8 |
| Median activity | 5.96 |
| Endpoint | Measurements |
|---|---|
| Ki | 8,925 |
| IC50 | 7,553 |
| EC50 | 69 |
| Kd | 46 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 2,169 |
| Three | 396 |
| Four or more | 307 |
| Family | Shared compounds |
|---|---|
| Family A G protein-coupled receptor | 1,980 |
| Voltage-gated ion channel | 477 |
| Cytochrome P450 | 473 |
| Oxidoreductase | 253 |
| Primary active transporter | 208 |
| Kinase | 130 |