Enzymes that break a bond using water.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 5,879 |
| Activity range, pActivity | 1.12 to 11.92 |
| Median activity | 5.72 |
| Endpoint | Measurements |
|---|---|
| IC50 | 4,624 |
| Kd | 731 |
| Ki | 520 |
| EC50 | 4 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 1,914 |
| Three | 129 |
| Four or more | 163 |
| Family | Shared compounds |
|---|---|
| Protease | 777 |
| Oxidoreductase | 522 |
| Kinase | 291 |
| Family A G protein-coupled receptor | 203 |
| Cytochrome P450 | 196 |
| Voltage-gated ion channel | 175 |