A protein family as ChEMBL classifies it.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 383 |
| Activity range, pActivity | 2.22 to 10.68 |
| Median activity | 6.22 |
| Endpoint | Measurements |
|---|---|
| IC50 | 287 |
| Ki | 58 |
| Kd | 22 |
| EC50 | 16 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 101 |
| Three | 19 |
| Four or more | 31 |
| Family | Shared compounds |
|---|---|
| Voltage-gated ion channel | 49 |
| Oxidoreductase | 45 |
| Cytochrome P450 | 42 |
| Nuclear receptor | 22 |
| Kinase | 19 |
| Electrochemical transporter | 17 |